Shuhong Han,
RES AST PROF
Department:
MD-RHEUMATOLOGY
Business Phone:
(352) 274-8217
Business Email:
shuhong.han@medicine.ufl.edu
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-6951-120X
Publications
2024
MEK1/2 and ERK1/2 mediated lung endothelial injury and altered hemostasis promote diffuse alveolar hemorrhage in murine lupus.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.05.07.593006.
[PMID] 38766226.
2024
MEK1/2- and ERK1/2-Mediated Lung Endothelial Injury and Altered Hemostasis Promote Diffuse Alveolar Hemorrhage in Murine Lupus.
Arthritis & rheumatology (Hoboken, N.J.).
76(10):1538-1551
[DOI] 10.1002/art.42936.
[PMID] 38923837.
2022
A novel monocyte differentiation pattern in pristane-induced lupus with diffuse alveolar hemorrhage
eLife.
11
[DOI] 10.7554/elife.76205.
2022
Author response: A novel monocyte differentiation pattern in pristane-induced lupus with diffuse alveolar hemorrhage
.
[DOI] 10.7554/elife.76205.sa2.
2022
Microvascular lung injury and endoplasmic reticulum stress in systemic lupus erythematosus-associated alveolar hemorrhage and pulmonary vasculitis.
American journal of physiology. Lung cellular and molecular physiology.
323(6):L715-L729
[DOI] 10.1152/ajplung.00051.2022.
[PMID] 36255715.
2021
Microscopic Polyangiitis With Diffuse Alveolar Hemorrhage and Glomerulonephritis Complicating Acute Influenza Infection.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.
27(8S):S618-S619
[DOI] 10.1097/RHU.0000000000001730.
[PMID] 33843777.
2021
Myxomavirus serpin alters macrophage function and prevents diffuse alveolar hemorrhage in pristane-induced lupus.
Clinical immunology (Orlando, Fla.).
229
[DOI] 10.1016/j.clim.2021.108764.
[PMID] 34089860.
2020
Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon
Arthritis & Rheumatology.
72(1):100-113
[DOI] 10.1002/art.41072.
[PMID] 31390156.
2020
NF‐E2–Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus
Arthritis & Rheumatology.
72(10):1707-1720
[DOI] 10.1002/art.41383.
[PMID] 32500632.
2019
High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage
JCI Insight.
4(15)
[DOI] 10.1172/jci.insight.129703.
[PMID] 31391335.
2019
Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice.
Mediators of inflammation.
2019
[DOI] 10.1155/2019/1567179.
[PMID] 31281225.
2019
The Association between Depression and Type 1 Diabetes Mellitus: Inflammatory Cytokines as Ferrymen in between?
Mediators of inflammation.
2019
[DOI] 10.1155/2019/2987901.
[PMID] 31049023.
2018
Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.
Frontiers in immunology.
9
[DOI] 10.3389/fimmu.2018.00135.
[PMID] 29456535.
2017
A Novel Subset of Anti-Inflammatory CD138+ Macrophages Is Deficient in Mice with Experimental Lupus.
Journal of immunology (Baltimore, Md. : 1950).
199(4):1261-1274
[DOI] 10.4049/jimmunol.1700099.
[PMID] 28696256.
2017
Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus.
Arthritis & rheumatology (Hoboken, N.J.).
69(6):1280-1293
[DOI] 10.1002/art.40077.
[PMID] 28217966.
2016
“Lupoid hepatitis” in SLE patients and mice with experimental lupus.
Clinical immunology (Orlando, Fla.).
172:65-71
[DOI] 10.1016/j.clim.2016.07.007.
[PMID] 27430519.
2016
A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM.
Arthritis & rheumatology (Hoboken, N.J.).
68(12):2917-2928
[DOI] 10.1002/art.39781.
[PMID] 27274010.
2016
Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer’s-Like Mouse Model.
BioMed research international.
2016
[DOI] 10.1155/2016/7810196.
[PMID] 28042572.
2015
Animal Models of Interferon Signature Positive Lupus.
Frontiers in immunology.
6
[DOI] 10.3389/fimmu.2015.00291.
[PMID] 26097482.
2015
Maintenance of autoantibody production in pristane-induced murine lupus.
Arthritis research & therapy.
17
[DOI] 10.1186/s13075-015-0886-9.
[PMID] 26717913.
2015
Mechanisms of autoantibody production in systemic lupus erythematosus.
Frontiers in immunology.
6
[DOI] 10.3389/fimmu.2015.00228.
[PMID] 26029213.
2015
Mechanisms of tumor necrosis factor α antagonist-induced lupus in a murine model.
Arthritis & rheumatology (Hoboken, N.J.).
67(1):225-37
[DOI] 10.1002/art.38882.
[PMID] 25252121.
2015
STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells.
Immunology and cell biology.
93(5):461-71
[DOI] 10.1038/icb.2014.103.
[PMID] 25582338.
2014
Expression of recombinant human IL-4 in Pichia pastoris and relationship between its glycosylation and biological activity.
Protein expression and purification.
96:1-7
[DOI] 10.1016/j.pep.2014.01.005.
[PMID] 24468271.
2014
Toll-like receptor 7-stimulated tumor necrosis factor α causes bone marrow damage in systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.).
66(1):140-51
[DOI] 10.1002/art.38189.
[PMID] 24449581.
2013
Cd40 Exon 8 Deficiency Causes a Novel Form of Immunodeficiency With Hyper-Igm
Journal of Immunology.
190
2013
Novel autoantigens in type 1 diabetes.
American journal of translational research.
5(4):379-92
[PMID] 23724162.
2013
Novel detection of pancreatic and duodenal homeobox 1 autoantibodies (PAA) in human sera using luciferase immunoprecipitation systems (LIPS) assay.
International journal of clinical and experimental pathology.
6(6):1202-10
[PMID] 23696946.
2012
Characterization and Immunotherapeutic Implication of a Novel Cerebro-Spinal Fluid-Derived Alk-Positive Anaplastic Large Cell Lymphoma Cell Line
Blood.
120
2012
Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.
Journal of immunology (Baltimore, Md. : 1950).
188(8):4113-21
[DOI] 10.4049/jimmunol.1103113.
[PMID] 22422888.
2012
The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance.
Chemico-biological interactions.
195(1):52-60
[DOI] 10.1016/j.cbi.2011.10.007.
[PMID] 22079344.
2010
Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells from hematopoietic stem cells.
Journal of immune based therapies and vaccines.
8
[DOI] 10.1186/1476-8518-8-8.
[PMID] 21106069.
2010
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
PloS one.
5(7)
[DOI] 10.1371/journal.pone.0011726.
[PMID] 20668510.
2009
Immunity of lentiviral vector-modified dendritic cells.
Methods in molecular biology (Clifton, N.J.).
542:245-59
[DOI] 10.1007/978-1-59745-561-9_13.
[PMID] 19565906.
2009
Lentiviral calnexin-modified dendritic cells promote expansion of high-avidity effector T cells with central memory phenotype.
Immunology.
128(1):43-57
[DOI] 10.1111/j.1365-2567.2009.03067.x.
[PMID] 19689735.
2009
Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications.
Journal of hematology & oncology.
2
[DOI] 10.1186/1756-8722-2-34.
[PMID] 19660111.
2008
Overcoming immune tolerance against multiple myeloma with lentiviral calnexin-engineered dendritic cells.
Molecular therapy : the journal of the American Society of Gene Therapy.
16(2):269-79
[PMID] 18071334.
Grants
Sep 2017
– Aug 2023
PATHOGENESIS OF PRISTANE-INDUCED LUPUS
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Jul 2009
– Jun 2019
McKethan Professor Arthritis
Role: Principal Investigator
Funding: UF FOUNDATION
Contact Details
Phones:
- Business:
- (352) 274-8217
Emails:
- Business:
- shuhong.han@medicine.ufl.edu
Addresses:
- Business Mailing:
-
DEPT. OF MEDICINE, DIVISION OF RHEUMATOLOGY
PO BOX 100221
ARB R2-156
GAINESVILLE FL 326100221