Westley H Reeves

Westley H Reeves, M.D.

EM SCH & CHIEF

Department: MD-RHEUMATOLOGY
Business Phone: (352) 265-4846
Business Email: whreeves@ufl.edu

Teaching Profile

Courses Taught
2016,2018
MDT7200 Elect Top/Medicine
2021-2023
PAS5020 Intro to Medicine 2

Board Certifications

  • Internal Medicine
    American Board of Internal Medicine

Clinical Profile

Specialties
  • Rheumatology
Areas of Interest
  • Autoimmune disorders
  • Lupus – resources
  • Scleroderma
  • Scleroderma – resources
  • Sjögren syndrome
  • Systemic lupus erythematosus

Publications

2022
Clinical and Phenotypic Characterization of Common Variable Immunodeficiency Diagnosed in Younger and Older Adults.
Journal of clinical immunology. 42(6):1270-1279 [DOI] 10.1007/s10875-022-01290-w. [PMID] 35588029.
2021
Microscopic Polyangiitis With Diffuse Alveolar Hemorrhage and Glomerulonephritis Complicating Acute Influenza Infection.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 27(8S):S618-S619 [DOI] 10.1097/RHU.0000000000001730. [PMID] 33843777.
2021
Myxomavirus serpin alters macrophage function and prevents diffuse alveolar hemorrhage in pristane-induced lupus.
Clinical immunology (Orlando, Fla.). 229 [DOI] 10.1016/j.clim.2021.108764. [PMID] 34089860.
2021
Reply.
Arthritis & rheumatology (Hoboken, N.J.). 73(1):176-178 [DOI] 10.1002/art.41478. [PMID] 32776428.
2020
Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon.
Arthritis & rheumatology (Hoboken, N.J.). 72(1):100-113 [DOI] 10.1002/art.41072. [PMID] 31390156.
2020
NF-E2-Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus.
Arthritis & rheumatology (Hoboken, N.J.). 72(10):1707-1720 [DOI] 10.1002/art.41383. [PMID] 32500632.
2019
Effects of irisin on the differentiation and browning of human visceral white adipocytes.
American journal of translational research. 11(12):7410-7421 [PMID] 31934288.
2019
High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage.
JCI insight. 4(15) [DOI] 10.1172/jci.insight.129703. [PMID] 31391335.
2018
Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.
Biochemistry. 57(7):1096-1107 [DOI] 10.1021/acs.biochem.7b01171. [PMID] 29227673.
2018
Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.00135. [PMID] 29456535.
2017
A Novel Subset of Anti-Inflammatory CD138+ Macrophages Is Deficient in Mice with Experimental Lupus.
Journal of immunology (Baltimore, Md. : 1950). 199(4):1261-1274 [DOI] 10.4049/jimmunol.1700099. [PMID] 28696256.
2017
Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus.
Arthritis & rheumatology (Hoboken, N.J.). 69(6):1280-1293 [DOI] 10.1002/art.40077. [PMID] 28217966.
2017
Tubulointerstitial Nephritis in Sjögren Syndrome Treated With Mycophenolate Mofetil.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 23(7):402-403 [DOI] 10.1097/RHU.0000000000000595. [PMID] 28937480.
2016
“Lupoid hepatitis” in SLE patients and mice with experimental lupus.
Clinical immunology (Orlando, Fla.). 172:65-71 [DOI] 10.1016/j.clim.2016.07.007. [PMID] 27430519.
2016
A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM.
Arthritis & rheumatology (Hoboken, N.J.). 68(12):2917-2928 [DOI] 10.1002/art.39781. [PMID] 27274010.
2016
Angiopoietin-like protein 8 (betatrophin) is a stress-response protein that down-regulates expression of adipocyte triglyceride lipase.
Biochimica et biophysica acta. 1861(2):130-137 [DOI] 10.1016/j.bbalip.2015.11.003. [PMID] 26569053.
2016
Irisin exerts dual effects on browning and adipogenesis of human white adipocytes.
American journal of physiology. Endocrinology and metabolism. 311(2):E530-41 [DOI] 10.1152/ajpendo.00094.2016. [PMID] 27436609.
2016
Muscarinic type 3 receptor autoantibodies are associated with anti-SSA/Ro autoantibodies in Sjögren’s syndrome.
Journal of immunological methods. 437:28-36 [DOI] 10.1016/j.jim.2016.07.003. [PMID] 27460476.
2016
Norovirus antagonism of B-cell antigen presentation results in impaired control of acute infection.
Mucosal immunology. 9(6):1559-1570 [DOI] 10.1038/mi.2016.15. [PMID] 27007673.
2016
Sjögren’s syndrome-associated microRNAs in CD14(+) monocytes unveils targeted TGFβ signaling.
Arthritis research & therapy. 18(1) [DOI] 10.1186/s13075-016-0987-0. [PMID] 27142093.
2015
Animal Models of Interferon Signature Positive Lupus.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00291. [PMID] 26097482.
2015
Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts.
PloS one. 10(8) [DOI] 10.1371/journal.pone.0136816. [PMID] 26305684.
2015
Maintenance of autoantibody production in pristane-induced murine lupus.
Arthritis research & therapy. 17 [DOI] 10.1186/s13075-015-0886-9. [PMID] 26717913.
2015
Mechanisms of autoantibody production in systemic lupus erythematosus.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00228. [PMID] 26029213.
2015
Mechanisms of tumor necrosis factor α antagonist-induced lupus in a murine model.
Arthritis & rheumatology (Hoboken, N.J.). 67(1):225-37 [DOI] 10.1002/art.38882. [PMID] 25252121.
2015
TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis.
Journal of immunology (Baltimore, Md. : 1950). 194(3):1169-77 [DOI] 10.4049/jimmunol.1302676. [PMID] 25548220.
2014
Editorial: systemic lupus erythematosus: death by fire and ICE?
Arthritis & rheumatology (Hoboken, N.J.). 66(1):6-9 [DOI] 10.1002/art.38224. [PMID] 24449570.
2014
Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus.
Arthritis research & therapy. 16(1) [DOI] 10.1186/ar4448. [PMID] 24451065.
2014
Induced murine models of systemic lupus erythematosus.
Methods in molecular biology (Clifton, N.J.). 1134:103-30 [DOI] 10.1007/978-1-4939-0326-9_9. [PMID] 24497358.
2014
Phenotypic Consequences of Tlr7-Driven Interferon and Proinflammatory Cytokine Production in Lupus
Arthritis Research & Therapy. 16(1)
2014
Positive correlation of STAT1 and miR-146a with anemia in patients with systemic lupus erythematosus.
Journal of clinical immunology. 34(2):171-80 [DOI] 10.1007/s10875-013-9973-3. [PMID] 24292724.
2014
Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset.
Arthritis research & therapy. 16(1) [DOI] 10.1186/ar4451. [PMID] 24460726.
2014
Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin.
Clinical immunology (Orlando, Fla.). 154(1):49-65 [DOI] 10.1016/j.clim.2014.06.007. [PMID] 24971701.
2014
Toll-like receptor 7-stimulated tumor necrosis factor α causes bone marrow damage in systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.). 66(1):140-51 [DOI] 10.1002/art.38189. [PMID] 24449581.
2013
Anti-Th/To Antibodies in Various Systemic Rheumatic Diseases Screened By Anti-Rpp25 Elisa.
Arthritis and Rheumatism. 65:S287-S288
2013
Breast implant-associated ALK-negative anaplastic large cell lymphoma: a case report and discussion of possible pathogenesis.
International journal of clinical and experimental pathology. 6(8):1631-42 [PMID] 23923082.
2013
Cd40 Exon 8 Deficiency Causes a Novel Form of Immunodeficiency With Hyper-Igm
Journal of Immunology. 190
2013
Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells.
Journal of immunology (Baltimore, Md. : 1950). 190(8):3916-27 [DOI] 10.4049/jimmunol.1201880. [PMID] 23509349.
2013
Neutrophil Gelatinase Associated Lipocalin (Ngal) Regulates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Journal of Immunology. 190
2013
Neutrophil Gelatinase Associated Lipocalin (Ngal) Regulates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Journal of Immunology. 190
2013
Neutrophil Gelatinase Associated Lipocalin (Ngal/Lipocalin-2) Regulates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Arthritis and Rheumatism. 65
2013
Novel autoantigens in type 1 diabetes.
American journal of translational research. 5(4):379-92 [PMID] 23724162.
2013
Novel detection of pancreatic and duodenal homeobox 1 autoantibodies (PAA) in human sera using luciferase immunoprecipitation systems (LIPS) assay.
International journal of clinical and experimental pathology. 6(6):1202-10 [PMID] 23696946.
2013
Regulation of Aberrant Cd4 T Cell Activation By Suppressor of Cytokine Signaling-1 (Socs1) Mimetic Peptide, Has Relevance To Human Systemic Lupus Erythematosus
Arthritis and Rheumatism. 65:S1163-S1164
2013
The reprogrammed pancreatic progenitor-like intermediate state of hepatic cells is more susceptible to pancreatic beta cell differentiation.
Journal of cell science. 126(Pt 16):3638-48 [DOI] 10.1242/jcs.124925. [PMID] 23750005.
2012
A New Linked Set of Autoantibodies in Dermatomyositis: Anti-Mi-2 and Anti-Transcription Intermediary Factor (Tif) 1Alpha.
Arthritis and Rheumatism. 64
2012
Autoantibodies To Survival of Motor Neuron (Smn) Complex Are Common in Patients With Anti-U1Rnp/Sm and Are Associated With Features of Scleroderma and Myopathy.
Arthritis and Rheumatism. 64:S305-S306
2012
Autoantibodies to transcription intermediary factor TIF1β associated with dermatomyositis.
Arthritis research & therapy. 14(2) [DOI] 10.1186/ar3802. [PMID] 22513056.
2012
Characterization and Immunotherapeutic Implication of a Novel Cerebro-Spinal Fluid-Derived Alk-Positive Anaplastic Large Cell Lymphoma Cell Line
Blood. 120
2012
Clinical Features Associated With Anti-Th/To in Non-Scleroderma Patients – Sine Scleroderma?
Arthritis and Rheumatism. 64:S631-S632
2012
Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with systemic lupus erythematosus: two cases without features of scleroderma.
Lupus. 21(1):68-74 [DOI] 10.1177/0961203311422712. [PMID] 22025191.
2012
Correlation of Signal Transducers and Activators of Transcription-1 and Microrna-146a With Anaemia and Other Clinical Features in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism. 64
2012
Effects of Treatment On the Expression of Ccl2 and Cxcl10 in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism. 64
2012
Gemin5 Is a New Target of Autoantibodies That Are Produced in Tight Connection With Antibodies To Snrnps and Survival of Motor Neuron (Smn) Complex
Arthritis and Rheumatism. 64
2012
Neutrophil Gelatinase Associated Lipocalin (Ngal) Deficiency Accelerates the Onset of Serum Autoantibodies in Pristane Induced Lupus
Journal of Immunology. 188
2012
Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.
Journal of immunology (Baltimore, Md. : 1950). 188(8):4113-21 [DOI] 10.4049/jimmunol.1103113. [PMID] 22422888.
2011
A Novel Circulating Cxcr5-Cd20++ B Cell Compartment in Patients With Systemic Lupus Erythematosus
Arthritis and Rheumatism. 63
2011
Altered miR-146a expression in Sjögren’s syndrome and its functional role in innate immunity.
European journal of immunology. 41(7):2029-39 [DOI] 10.1002/eji.201040757. [PMID] 21469088.
2011
Atypical clinical presentation of a subset of patients with anti-RNA polymerase III–non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining.
Arthritis research & therapy. 13(4) [DOI] 10.1186/ar3422. [PMID] 21781293.
2011
Autoantibodies to survival of motor neuron complex in patients with polymyositis: immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins.
Arthritis and rheumatism. 63(7):1972-8 [DOI] 10.1002/art.30349. [PMID] 21425128.
2011
Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.
Infection and immunity. 79(7):2746-54 [DOI] 10.1128/IAI.01291-10. [PMID] 21518789.
2011
Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.
Arthritis research & therapy. 13(3) [DOI] 10.1186/ar3387. [PMID] 21708033.
2011
Distinctive Pattern of Myositis-Specific Autoantibody Production Between American Caucasian and Italian Patients With Polymyositis/Dermatomyositis
Arthritis and Rheumatism. 63
2011
Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study.
Arthritis research & therapy. 13(3) [DOI] 10.1186/ar3334. [PMID] 21569292.
2011
Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies.
Clinical rheumatology. 30(10):1333-9 [DOI] 10.1007/s10067-011-1751-0. [PMID] 21523365.
2011
IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil.
Journal of immunology (Baltimore, Md. : 1950). 186(3):1747-54 [DOI] 10.4049/jimmunol.1001328. [PMID] 21191074.
2011
Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane.
Laboratory investigation; a journal of technical methods and pathology. 91(10):1540-50 [DOI] 10.1038/labinvest.2011.108. [PMID] 21808234.
2011
Transcription Intermediary Factor (Tif)-1 Beta Is a New Dermatomyositis Autoantigen
Arthritis and Rheumatism. 63
2010
Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.
Journal of neuroimmunology. 223(1-2):13-9 [DOI] 10.1016/j.jneuroim.2010.03.018. [PMID] 20416954.
2010
Extraordinary antigenicity of the human Ro52 autoantigen.
American journal of translational research. 2(2):145-55 [PMID] 20407604.
2010
Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells.
Immunology and cell biology. 88(2):205-12 [DOI] 10.1038/icb.2009.84. [PMID] 19918258.
2010
Monocyte and macrophage abnormalities in systemic lupus erythematosus.
Archivum immunologiae et therapiae experimentalis. 58(5):355-64 [DOI] 10.1007/s00005-010-0093-y. [PMID] 20676786.
2010
Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus.
Arthritis research & therapy. 12(3) [DOI] 10.1186/ar3017. [PMID] 20478071.
2010
Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes.
Laboratory investigation; a journal of technical methods and pathology. 90(1):31-9 [DOI] 10.1038/labinvest.2009.116. [PMID] 19901909.
2009
Altered Homeostasis of Cd4+Memory T Cells in Peripheral Blood of Active Lupus Patients
Journal of Allergy and Clinical Immunology. 123(2):340-S91 [DOI] 10.1016/j.jaci.2008.12.324.
2009
Autoantibody to NA14 is an independent marker primarily for Sjogren’s syndrome.
Frontiers in bioscience (Landmark edition). 14(10):3733-9 [DOI] 10.2741/3484. [PMID] 19273306.
2009
B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus.
Journal of immunology (Baltimore, Md. : 1950). 182(7):4226-36 [DOI] 10.4049/jimmunol.0800771. [PMID] 19299721.
2009
Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis.
The Journal of rheumatology. 36(12):2682-90 [DOI] 10.3899/jrheum.090338. [PMID] 19884269.
2009
Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.
Arthritis research & therapy. 11(1) [DOI] 10.1186/ar2590. [PMID] 19144150.
2009
Indole-3-carbinol improves survival in lupus-prone mice by inducing tandem B- and T-cell differentiation blockades.
Clinical immunology (Orlando, Fla.). 131(3):481-94 [DOI] 10.1016/j.clim.2009.01.013. [PMID] 19278904.
2009
Induction of autoimmunity by pristane and other naturally occurring hydrocarbons.
Trends in immunology. 30(9):455-64 [DOI] 10.1016/j.it.2009.06.003. [PMID] 19699150.
2009
Rapid serological detection of autoantibodies associated with Sjögren’s syndrome.
Journal of translational medicine. 7 [DOI] 10.1186/1479-5876-7-83. [PMID] 19778440.
2009
Type I interferon modulates monocyte recruitment and maturation in chronic inflammation.
The American journal of pathology. 175(5):2023-33 [DOI] 10.2353/ajpath.2009.090328. [PMID] 19808647.
2008
A novel type I IFN-producing cell subset in murine lupus.
Journal of immunology (Baltimore, Md. : 1950). 180(7):5101-8 [PMID] 18354236.
2008
Clinical Significance of Autoantibodies To Topoisomerase I and Rna Polymerase Iii in An Unselected Rheumatic Disease Population
Arthritis and Rheumatism. 58:S372-S373
2008
Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen.
Journal of immunology (Baltimore, Md. : 1950). 181(5):3259-67 [PMID] 18713997.
2008
High Affinity Fc Gamma Receptor Ri (Cd64), a Potential Biomarker To Monitor Type-I-Ifn Levels and Disease Activity in Sle
Arthritis and Rheumatism. 58
2008
Labial salivary gland biopsies in Sjögren’s syndrome: still the gold standard?
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 106(3):392-402 [DOI] 10.1016/j.tripleo.2008.04.018. [PMID] 18602295.
2008
Patients with pulmonary tuberculosis are frequently positive for anti-cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptide.
Arthritis and rheumatism. 58(6):1576-81 [DOI] 10.1002/art.23514. [PMID] 18512773.
2008
Salivary dysfunction and quality of life in Sjögren syndrome: a critical oral-systemic connection.
Journal of the American Dental Association (1939). 139(3):291-9; quiz 358 [PMID] 18310733.
2008
Significant Racial and Gender Differences in Specificity of Scleroderma-Related Autoantibodies
Arthritis and Rheumatism. 58
2008
Tlr-7-Dependent and Fc Gamma R-Independent Production of Type I Interferon in Experimental Murine Lupus
Arthritis and Rheumatism. 58
2008
TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus.
The Journal of experimental medicine. 205(13):2995-3006 [DOI] 10.1084/jem.20080462. [PMID] 19047436.
2008
Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients.
Arthritis research & therapy. 10(4) [DOI] 10.1186/ar2493. [PMID] 18759964.
2007
AutoAbSC.Org — Autoantibody Standardization Committee in 2006.
Autoimmunity reviews. 6(8):577-80 [PMID] 17854752.
2007
Autoantibodies to RNA helicase A: a new serologic marker of early lupus.
Arthritis and rheumatism. 56(2):596-604 [PMID] 17265494.
2007
Clinical implication of autoantibodies in patients with systemic rheumatic diseases.
Expert review of clinical immunology. 3(5):721-38 [DOI] 10.1586/1744666X.3.5.721. [PMID] 20477023.
2007
Deficiency of the type I interferon receptor protects mice from experimental lupus.
Arthritis and rheumatism. 56(11):3770-83 [PMID] 17968932.
2007
Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells.
Nucleic acids research. 35(7):2302-10 [PMID] 17389650.
2007
In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen.
Arthritis and rheumatism. 56(10):3379-86 [PMID] 17907192.
2007
Malar rash caused by metal allergy in a patient with systemic lupus erythematosus.
Nature clinical practice. Rheumatology. 3(4):240-5 [PMID] 17396110.
2007
Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.
Blood. 110(10):3673-81 [PMID] 17690255.
2007
Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Arthritis and rheumatism. 56(11):3759-69 [PMID] 17968925.
2006
“Endogenous adjuvant” activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.
Arthritis and rheumatism. 54(5):1557-67 [PMID] 16645989.
2006
Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases.
Arthritis research & therapy. 8(4) [PMID] 16846524.
2006
Autoimmune targeting of key components of RNA interference.
Arthritis research & therapy. 8(4) [PMID] 16684366.
2006
Cutaneous mastocytosis in a patient with primary Sjögren’s syndrome.
The Journal of rheumatology. 33(8):1697-700 [PMID] 16881127.
2006
Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody.
Journal of immunological methods. 317(1-2):38-44 [PMID] 17054975.
2006
Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950). 177(11):7943-9 [PMID] 17114466.
2006
Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice.
Toxicology. 218(2-3):186-96 [PMID] 16309812.
2006
International multicenter evaluation of autoantibodies to ribosomal P proteins.
Clinical and vaccine immunology : CVI. 13(1):77-83 [PMID] 16426003.
2006
Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p.
Arthritis and rheumatism. 54(5):1573-9 [PMID] 16645992.
2006
Nucleolar staining cannot be used as a screening test for the scleroderma marker anti-RNA polymerase I/III antibodies.
Arthritis and rheumatism. 54(9):3051-6 [PMID] 16948135.
2006
Role of non-protein amino acid L-canavanine in autoimmunity.
Autoimmunity reviews. 5(6):429-35 [PMID] 16890899.
2006
Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers.
Vaccine. 24(19):4035-40 [PMID] 16464519.
2006
Type I interferon as a target of treatment in SLE.
Endocrine, metabolic & immune disorders drug targets. 6(4):323-30 [PMID] 17214578.
2006
Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane).
The American journal of pathology. 168(4):1227-40 [PMID] 16565497.
2006
Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis.
Arthritis and rheumatism. 54(6):2004-9 [PMID] 16732549.
2005
Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.). 117(3):238-50 [PMID] 16126005.
2005
Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes.
Glia. 52(2):153-62 [PMID] 15920723.
2005
Effective use of autoantibody tests in the diagnosis of systemic autoimmune disease.
Annals of the New York Academy of Sciences. 1050:217-28 [PMID] 16014537.
2005
High sensitivity C-reactive protein in systemic lupus erythematosus: relation to disease activity, clinical presentation and implications for cardiovascular risk.
Lupus. 14(8):576-82 [PMID] 16175928.
2005
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.
The Journal of experimental medicine. 202(11):1575-85 [PMID] 16330816.
2005
Pristane-induced autoimmunity in germ-free mice.
Clinical immunology (Orlando, Fla.). 114(2):110-8 [PMID] 15639644.
2004
Autoantibodies that stabilize U1snRNP are a significant component of human autoantibodies to snRNP and delay proteolysis of sm antigens in vitro.
The Journal of rheumatology. 31(12):2382-9 [PMID] 15570638.
2004
Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 58(5):325-37 [PMID] 15194169.
2004
Cutting edge diagnostics in rheumatology: the role of patients, clinicians, and laboratory scientists in optimizing the use of autoimmune serology.
Arthritis and rheumatism. 51(2):291-8 [PMID] 15077275.
2004
Diagnostic accuracy for lupus and other systemic autoimmune diseases in the community setting.
Archives of internal medicine. 164(22):2435-41 [PMID] 15596633.
2004
Distinctive patterns of autoimmune response induced by different types of mineral oil.
Toxicological sciences : an official journal of the Society of Toxicology. 78(2):222-8 [PMID] 14718649.
2004
Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren’s syndrome.
Arthritis and rheumatism. 50(1):187-98 [PMID] 14730616.
2004
Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 production.
Journal of leukocyte biology. 76(1):227-36 [PMID] 15075356.
2004
Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis.
Arthritis and rheumatism. 50(6):1842-9 [PMID] 15188361.
2003
A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. III. Comparative performance characteristics of academic and manufacturers’ laboratories.
The Journal of rheumatology. 30(11):2374-81 [PMID] 14677180.
2003
Ecotropic murine leukemia viruses and exogenous mouse mammary tumor viruses are not essential for pristane-induced lupus.
Arthritis and rheumatism. 48(10):2990-2 [PMID] 14558108.
2003
Henry Kunkel, Stephanie Smith, clinical immunology, and split genes.
Lupus. 12(3):213-7 [PMID] 12708785.
2003
Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950). 171(4):2142-53 [PMID] 12902521.
2003
Induction of lupus autoantibodies by adjuvants.
Journal of autoimmunity. 21(1):1-9 [PMID] 12892730.
2003
Nephritogenic autoantibodies but absence of nephritis in Il-12p35-deficient mice with pristane-induced lupus.
Kidney international. 64(3):897-905 [PMID] 12911539.
2003
X-linked immunodeficient mice spontaneously produce lupus-related anti-RNA helicase A autoantibodies, but are resistant to pristane-induced lupus.
International immunology. 15(9):1117-24 [PMID] 12917264.
2002
A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. II. Potential for quantitation of antibody content.
The Journal of rheumatology. 29(1):68-74 [PMID] 11824974.
2002
Autoantibodies from an SLE patient immunostain the Barr body.
Cytogenetic and genome research. 97(1-2):28-31 [PMID] 12438734.
2002
Effect of an exogenous trigger on the pathogenesis of lupus in (NZB x NZW)F1 mice.
Arthritis and rheumatism. 46(8):2235-44 [PMID] 12209530.
2001
Increased prevalence of autoantibodies to ku antigen in African American versus white patients with systemic lupus erythematosus.
Arthritis and rheumatism. 44(10):2367-70 [PMID] 11665978.
2001
Interferon-gamma is required for lupus nephritis in mice treated with the hydrocarbon oil pristane.
Kidney international. 60(6):2173-80 [PMID] 11737591.
2001
Titration emulation: a computer-assisted technique that simplifies the quantification of anti-dsDNA antibodies using the Crithidia luciliae assay.
Lupus. 10(9):632-6 [PMID] 11678452.
2001
Tumor immunity and autoimmunity: a case of Dr. Jekyll and Mr. Hyde.
Clinical immunology (Orlando, Fla.). 100(2):129-33 [PMID] 11465940.
2000
Autoantibodies to DEK oncoprotein in human inflammatory disease.
Arthritis and rheumatism. 43(1):85-93 [PMID] 10643703.
2000
B cell subsets in pristane-induced autoimmunity.
Current topics in microbiology and immunology. 252:201-7 [PMID] 11125477.
2000
Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus.
Journal of immunology (Baltimore, Md. : 1950). 165(2):1036-43 [PMID] 10878381.
2000
Induction of hypergammaglobulinemia and macrophage activation by silicone gels and oils in female A.SW mice.
Clinical and diagnostic laboratory immunology. 7(3):366-70 [PMID] 10799447.
2000
Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane.
Clinical and experimental immunology. 121(2):399-405 [PMID] 10931159.
1999
Association of terminal deoxynucleotidyl transferase with Ku.
Proceedings of the National Academy of Sciences of the United States of America. 96(24):13926-31 [PMID] 10570175.
1999
Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity.
The Journal of biological chemistry. 274(49):34598-604 [PMID] 10574923.
1999
Disparate T cell requirements of two subsets of lupus-specific autoantibodies in pristane-treated mice.
Clinical and experimental immunology. 115(3):547-53 [PMID] 10193432.
1999
Immunopathogenesis of environmentally induced lupus in mice.
Environmental health perspectives. 107 Suppl 5(Suppl 5):723-7 [PMID] 10502537.
1999
Induction of B cell autoimmunity by pristane.
Current topics in microbiology and immunology. 246:387-92; discussion 393 [PMID] 10396079.
1999
Ku autoimmune antigen is involved in placental regulation of rat P450c17 gene transcription.
DNA and cell biology. 18(3):197-208 [PMID] 10098601.
1998
A model for Ku heterodimer assembly and interaction with DNA. Implications for the function of Ku antigen.
The Journal of biological chemistry. 273(47):31068-74 [PMID] 9813006.
1998
Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis.
Arthritis and rheumatism. 41(8):1505-10 [PMID] 9704652.
1998
Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding.
The Journal of biological chemistry. 273(2):842-8 [PMID] 9422740.
1998
Influence of microbial stimulation on hypergammaglobulinemia and autoantibody production in pristane-induced lupus.
Clinical immunology and immunopathology. 86(3):271-9 [PMID] 9557160.
1998
Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus.
The Journal of experimental medicine. 188(5):985-90 [PMID] 9730900.
1997
Human anti-nuclear ribonucleoprotein antigen autoimmune sera contain a novel subset of autoantibodies that stabilizes the molecular interaction of U1RNP-C protein with the Sm core proteins.
Journal of immunology (Baltimore, Md. : 1950). 158(10):5017-25 [PMID] 9144522.
1997
Human autoantibodies stabilize the quaternary structure of Ku antigen.
Arthritis and rheumatism. 40(7):1344-53 [PMID] 9214436.
1997
Initiation of autoimmunity to self-proteins complexed with viral antigens.
Annals of the New York Academy of Sciences. 815:139-54 [PMID] 9186651.
1997
Recombinant 52 kDa Ro(SSA) ELISA detects autoantibodies in Sjögren’s syndrome sera that go undetected by conventional serologic assays.
The Journal of rheumatology. 24(5):860-6 [PMID] 9150073.
1997
Reference sera for antinuclear antibodies. II. Further definition of antibody specificities in international antinuclear antibody reference sera by immunofluorescence and western blotting.
Arthritis and rheumatism. 40(3):413-8 [PMID] 9082926.
1996
Autoantibodies that stabilize the molecular interaction of Ku antigen with DNA-dependent protein kinase catalytic subunit.
Clinical and experimental immunology. 105(3):460-7 [PMID] 8809135.
1996
Autoantibodies to ribosomal P antigens with immune complex glomerulonephritis in SJL mice treated with pristane.
Journal of immunology (Baltimore, Md. : 1950). 157(7):3200-6 [PMID] 8816434.
1996
Characterization of a Ku86 variant protein that results in altered DNA binding and diminished DNA-dependent protein kinase activity.
The Journal of biological chemistry. 271(24):14098-104 [PMID] 8662896.
1996
Correlation of antisynthetase antibody levels with disease course in a patient with interstitial lung disease and elevated muscle enzymes.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2(2):89-95 [PMID] 19078036.
1996
Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein.
The Journal of clinical investigation. 97(11):2619-26 [PMID] 8647956.
1996
DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease.
The Journal of biological chemistry. 271(40):25035-40 [PMID] 8798786.
1996
Features of autoantigens.
Molecular biology reports. 23(3-4):217-26 [PMID] 9112232.
1996
Late development of anti-La/SS-B antibodies in a patient with Sjogren’s syndrome and high titer anti-Ro/SS-A antibodies.
Lupus. 5(4):337-9 [PMID] 8869909.
1996
p95vav associates with the nuclear protein Ku-70.
Molecular and cellular biology. 16(1):37-44 [PMID] 8524317.
1995
Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis.
The Journal of experimental medicine. 181(6):2049-58 [PMID] 7759997.
1995
Anti-nuclear antibody production and immune-complex glomerulonephritis in BALB/c mice treated with pristane.
Proceedings of the National Academy of Sciences of the United States of America. 92(24):10934-8 [PMID] 7479913.
1995
Autoantibodies to topoisomerase I in a patient with systemic lupus erythematosus without features of scleroderma.
Lupus. 4(4):314-7 [PMID] 8528230.
1995
Changing autoantibody profiles with variable clinical manifestations in a patient with relapsing systemic lupus erythematosus and polymyositis.
British journal of rheumatology. 34(10):915-9 [PMID] 7582695.
1995
Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.
Proceedings of the National Academy of Sciences of the United States of America. 92(3):890-4 [PMID] 7846073.
1995
Pristane induces high titers of anti-Su and anti-nRNP/Sm autoantibodies in BALB/c mice. Quantitation by antigen capture ELISAs based on monospecific human autoimmune sera.
Journal of immunological methods. 182(1):51-62 [PMID] 7769244.
1995
Role of free p70 (Ku) subunit in posttranslational stabilization of newly synthesized p80 during DNA-dependent protein kinase assembly.
European journal of cell biology. 66(2):127-35 [PMID] 7774599.
1994
Assembly and DNA binding of recombinant Ku (p70/p80) autoantigen defined by a novel monoclonal antibody specific for p70/p80 heterodimers.
Journal of cell science. 107 ( Pt 11):3223-33 [PMID] 7699019.
1994
Association of autoantibodies to topoisomerase I and the phosphorylated (IIO) form of RNA polymerase II in Japanese scleroderma patients.
Journal of immunology (Baltimore, Md. : 1950). 153(12):5838-48 [PMID] 7989779.
1994
Autoantibodies to RNA polymerase II are common in systemic lupus erythematosus and overlap syndrome. Specific recognition of the phosphorylated (IIO) form by a subset of human sera.
The Journal of clinical investigation. 94(5):1981-9 [PMID] 7962544.
1994
Induction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane.
The Journal of experimental medicine. 180(6):2341-6 [PMID] 7964507.
1994
Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen.
The Journal of experimental medicine. 179(4):1243-52 [PMID] 8145041.
1994
Onset of polymyositis with autoantibodies to threonyl-tRNA synthetase during pregnancy.
The Journal of rheumatology. 21(8):1564-6 [PMID] 7983666.
1994
Similar DNA binding properties of free P70 (KU) subunit and P70/P80 heterodimer.
FEBS letters. 351(2):219-24 [PMID] 8082768.
1994
Systemic lupus erythematosus. Antibodies to DNA, DNA-binding proteins, and histones.
Rheumatic diseases clinics of North America. 20(1):1-28 [PMID] 8153395.
1993
Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens.
Molecular biology reports. 18(1):15-28 [PMID] 7694076.
1992
Antibodies to the p70/p80 (Ku) antigens in systemic lupus erythematosus.
Rheumatic diseases clinics of North America. 18(2):391-414 [PMID] 1626075.
1992
B-cell epitopes of autoantigenic DNA-binding proteins.
Molecular biology reports. 16(3):191-8 [PMID] 1380643.
1992
Molecular analysis of autoantibody production.
Concepts in immunopathology. 8:38-70 [PMID] 1735105.
1992
Recognition of multiple epitopes in the coiled-coil domain of lamin B by human autoantibodies.
Molecular immunology. 29(9):1055-64 [PMID] 1379677.
1992
Role of a major autoepitope in forming the DNA binding site of the p70 (Ku) antigen.
The Journal of experimental medicine. 175(6):1677-84 [PMID] 1375268.
1991
Autoimmune mechanisms in psoriasis.
Seminars in dermatology. 10(3):217-24 [PMID] 1931571.
1991
Epitopes of the p70 and p80 (Ku) lupus autoantigens.
Journal of immunology (Baltimore, Md. : 1950). 146(8):2678-86 [PMID] 1707916.
1991
Onset and regulation of anti-lamin B autoantibody production is independent of the level of polyclonal activation.
Autoimmunity. 8(4):297-305 [PMID] 1932514.
1990
Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between species.
Journal of immunology (Baltimore, Md. : 1950). 145(12):4222-8 [PMID] 1701785.
1990
Immunopathogenesis of systemic lupus erythematosus and Sjögren’s syndrome.
Current opinion in rheumatology. 2(5):717-23 [PMID] 2148265.
1989
Acquired congenital heart block. Pattern of maternal antibody response to biochemically defined antigens of the SSA/Ro-SSB/La system in neonatal lupus.
The Journal of clinical investigation. 84(2):627-34 [PMID] 2760204.
1989
Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen.
The Journal of biological chemistry. 264(9):5047-52 [PMID] 2466842.
1989
Preferential use of lambda L chain in lamin B autoantibodies.
Journal of immunology (Baltimore, Md. : 1950). 143(11):3614-8 [PMID] 2511246.
1989
Role of antigen selectivity in autoimmune responses to the Ku (p70/p80) antigen.
The Journal of clinical investigation. 84(2):562-7 [PMID] 2527251.
1988
Multiple factors are required for poly(A) addition to a mRNA 3′ end.
Genes & development. 2(5):588-97 [PMID] 3384332.
1987
Antinuclear antibodies as probes to explore the structural organization of the genome.
The Journal of rheumatology. Supplement. 14 Suppl 13:97-105 [PMID] 3497271.
1987
Description and partial characterization of a nucleolar RNA-associated autoantigen defined by a human monoclonal antibody.
The Journal of experimental medicine. 165(4):1172-87 [PMID] 2435834.
1987
Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus.
The Journal of experimental medicine. 165(3):750-62 [PMID] 3546581.
1986
Human autoantibodies reactive with the signal-recognition particle.
Proceedings of the National Academy of Sciences of the United States of America. 83(24):9507-11 [PMID] 2432596.
1986
Interaction between anti-DNA and anti-DNA-binding protein autoantibodies in cryoglobulins from sera of patients with systemic lupus erythematosus.
The Journal of experimental medicine. 164(4):1029-42 [PMID] 3489804.
1986
Psoriasis and Raynaud’s phenomenon associated with autoantibodies to U1 and U2 small nuclear ribonucleoproteins.
The New England journal of medicine. 315(2):105-11 [PMID] 2941686.
1985
Autoimmune sera reactive with Sm antigen contain high levels of RNP-like antibodies.
The Journal of clinical investigation. 75(2):580-7 [PMID] 3973019.
1985
Small nuclear ribonucleoprotein particle assembly in vivo: demonstration of a 6S RNA-free core precursor and posttranslational modification.
Cell. 42(3):751-8 [PMID] 2932224.
1985
Temporal shifts from Sm to ribonucleoprotein reactivity in systemic lupus erythematosus.
Arthritis and rheumatism. 28(12):1348-55 [PMID] 2417607.
1985
Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune sera.
The Journal of experimental medicine. 161(1):18-39 [PMID] 2578541.
1984
Pulse labeling of small nuclear ribonucleoproteins in vivo reveals distinct patterns of antigen recognition by human autoimmune antibodies.
Proceedings of the National Academy of Sciences of the United States of America. 81(10):3185-9 [PMID] 6203115.
1983
Synthesis and assembly of human small nuclear ribonucleoproteins generated by cell-free translation.
Proceedings of the National Academy of Sciences of the United States of America. 80(20):6356-60 [PMID] 6226047.
1979
The echocardiogram in scleroderma endocarditis of the mitral valve.
Archives of internal medicine. 139(10):1179-80 [PMID] 485753.
1976
The use of a single venous blood sample to assess oxygen binding in haemoglobin.
British journal of haematology. 32(1):89-98 [PMID] 4084.
1956
Exacerbation of lupus erythematosus following splenectomy in idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia.
The American journal of medicine. 21(4):560-6 [PMID] 13362287.

Grants

Sep 2017 ACTIVE
PATHOGENESIS OF PRISTANE-INDUCED LUPUS
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Aug 2016 – Aug 2021
Miscellaneous Donors
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Feb 2014 – Jan 2018
Bone marrow stem cell niche dysfunction in human SLE
Role: Project Manager
Funding: LUPUS RES INST
Sep 2011 – Aug 2017
Pathogenesis of Autoantibodies in Pristane-Induced Lupus
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
May 2010 – Apr 2016
IMMUNOLOGIC/GENETIC MECHANICSMS IN RHEUMATIC DISEASES
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Jul 2008 – Mar 2018
Autoimmune Disease Research and Education
Role: Principal Investigator
Funding: UF FOUNDATION
Feb 2007 – Jun 2019
Schott Esc Rheum Arthritis II UFF# F002560
Role: Principal Investigator
Funding: UF FOUNDATION
Oct 2006 – Jun 2019
Schott ESC Rheum Arthritis I
Role: Principal Investigator
Funding: UF FOUNDATION

Education

Fellowship
1985 · Rockefeller University
Residency – Internal Medicine
1982 · Columbia Presbyterian Medical Center
Medical Degree
1979 · Yale University

Contact Details

Phones:
Business:
(352) 265-4846
Emails:
Business:
whreeves@ufl.edu
Addresses:
Business Mailing:
UNIVERSITY OF FLORIDA
PO BOX 100221
DIVISION OF RHEUMATOLOGY AND CLINICAL IMMUNO
GAINESVILLE FL 326100221
Business Street:
R3-110
GAINESVILLE FL 32611