Eric S Sobel

Eric S Sobel, M.D., Ph.D.

Associate Professor, Program Director

Department: MD-RHEUMATOLOGY
Business Phone: (352) 265-4846
Business Email: eric.sobel@medicine.ufl.edu

Accomplishments

Exemplary Teacher Award
2019 · College of Medicine

Teaching Profile

Courses Taught
2018
PAS5170 Rheumatology
2018
GMS7980 Research for Doctoral Dissertation
2016,2018
MDC7200 Medicine Clerkship
2018
MDC7203 Senior Medicine Clerk
2013-2018
MDT7200 Elect Top/Medicine
2010-2013
MEL7948 Elect Top/Medicine

Board Certifications

  • Rheumatology
    American Board of Internal Medicine

Clinical Profile

Specialties
  • Rheumatology
Areas of Interest
  • Dermatomyositis
  • Polymyositis – adult
  • Rheumatoid arthritis
  • Scleroderma
  • Scleroderma – resources
  • Sjögren syndrome
  • Systemic lupus erythematosus

Publications

2020
Autoimmune inner ear disease: A systematic review of management.
Laryngoscope investigative otolaryngology. 5(6):1217-1226 [DOI] 10.1002/lio2.508. [PMID] 33364414.
2020
Immunophenotyping reveals distinct subgroups of lupus patients based on their activated T cell subsets.
Clinical immunology (Orlando, Fla.). 221 [DOI] 10.1016/j.clim.2020.108602. [PMID] 33007439.
2019
Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells.
Journal of immunology (Baltimore, Md. : 1950). 203(2):338-348 [DOI] 10.4049/jimmunol.1801651. [PMID] 31160534.
2019
The utility of trough mycophenolic acid levels for the management of lupus nephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 34(1):83-89 [DOI] 10.1093/ndt/gfy026. [PMID] 29548021.
2016
A case of isolated renal involvement of polyarteritis nodosa successfully treated with steroid monotherapy.
BMJ case reports. 2016 [DOI] 10.1136/bcr-2016-215702. [PMID] 27440849.
2016
A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM.
Arthritis & rheumatology (Hoboken, N.J.). 68(12):2917-2928 [DOI] 10.1002/art.39781. [PMID] 27274010.
2015
Normalization of CD4+ T cell metabolism reverses lupus.
Science translational medicine. 7(274) [DOI] 10.1126/scitranslmed.aaa0835. [PMID] 25673763.
2015
Serpin treatment suppresses inflammatory vascular lesions in temporal artery implants (TAI) from patients with giant cell arteritis.
PloS one. 10(2) [DOI] 10.1371/journal.pone.0115482. [PMID] 25658487.
2014
Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus.
Arthritis research & therapy. 16(1) [DOI] 10.1186/ar4448. [PMID] 24451065.
2014
Increased IFN-α-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-α production.
Journal of immunology (Baltimore, Md. : 1950). 193(3):1024-34 [DOI] 10.4049/jimmunol.1303230. [PMID] 24973447.
2014
Osteoarthritis and psoriatic arthritis: findings in three-dimensional biophotonics imaging.
Bio-medical materials and engineering. 24(6):3063-71 [DOI] 10.3233/BME-141128. [PMID] 25227015.
2014
Positive correlation of STAT1 and miR-146a with anemia in patients with systemic lupus erythematosus.
Journal of clinical immunology. 34(2):171-80 [DOI] 10.1007/s10875-013-9973-3. [PMID] 24292724.
2014
Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset.
Arthritis research & therapy. 16(1) [DOI] 10.1186/ar4451. [PMID] 24460726.
2014
The Combination of Metformin and 2-Deoxy-D-Glucose Normalizes Cd4 T Cell Metabolism and Functions, and Reverse Disease in Murine Models of Lupus.
Arthritis & Rheumatology. 66(10, SI)
2013
Anti-Th/To Antibodies in Various Systemic Rheumatic Diseases Screened By Anti-Rpp25 Elisa.
Arthritis and Rheumatism. 65:S287-S288
2013
Cd40 Exon 8 Deficiency Causes a Novel Form of Immunodeficiency With Hyper-Igm
Journal of Immunology. 190
2013
Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells.
Journal of immunology (Baltimore, Md. : 1950). 190(8):3916-27 [DOI] 10.4049/jimmunol.1201880. [PMID] 23509349.
2013
Noninvasive Imaging of Hemoglobin Concentration and Oxygen Saturation for Detection of Osteoarthritis in the Finger Joints Using Multispectral Three-Dimensional Quantitative Photoacoustic Tomography
Journal of Optics. 15(5) [DOI] 10.1088/2040-8978/15/5/055302.
2012
A New Linked Set of Autoantibodies in Dermatomyositis: Anti-Mi-2 and Anti-Transcription Intermediary Factor (Tif) 1Alpha.
Arthritis and Rheumatism. 64
2012
Autoantibodies To Survival of Motor Neuron (Smn) Complex Are Common in Patients With Anti-U1Rnp/Sm and Are Associated With Features of Scleroderma and Myopathy.
Arthritis and Rheumatism. 64:S305-S306
2012
Autoantibodies to transcription intermediary factor TIF1β associated with dermatomyositis.
Arthritis research & therapy. 14(2) [DOI] 10.1186/ar3802. [PMID] 22513056.
2012
Clinical Features Associated With Anti-Th/To in Non-Scleroderma Patients – Sine Scleroderma?
Arthritis and Rheumatism. 64:S631-S632
2012
Clinical Features Associated With Anti-Th/To in Non-Scleroderma Patients – Sine Scleroderma?
Arthritis and Rheumatism. 64:S631-S632
2012
Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with systemic lupus erythematosus: two cases without features of scleroderma.
Lupus. 21(1):68-74 [DOI] 10.1177/0961203311422712. [PMID] 22025191.
2012
Correlation of Signal Transducers and Activators of Transcription-1 and Microrna-146a With Anaemia and Other Clinical Features in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism. 64
2012
Effects of Treatment On the Expression of Ccl2 and Cxcl10 in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism. 64
2012
Gemin5 Is a New Target of Autoantibodies That Are Produced in Tight Connection With Antibodies To Snrnps and Survival of Motor Neuron (Smn) Complex
Arthritis and Rheumatism. 64
2012
Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.
Journal of immunology (Baltimore, Md. : 1950). 188(2):604-14 [DOI] 10.4049/jimmunol.1002362. [PMID] 22180614.
2011
A Novel Circulating Cxcr5-Cd20++ B Cell Compartment in Patients With Systemic Lupus Erythematosus
Arthritis and Rheumatism. 63
2011
Atypical clinical presentation of a subset of patients with anti-RNA polymerase III–non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining.
Arthritis research & therapy. 13(4) [DOI] 10.1186/ar3422. [PMID] 21781293.
2011
Autoantibodies to survival of motor neuron complex in patients with polymyositis: immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins.
Arthritis and rheumatism. 63(7):1972-8 [DOI] 10.1002/art.30349. [PMID] 21425128.
2011
Computer-aided classification of optical images for diagnosis of osteoarthritis in the finger joints.
Journal of X-ray science and technology. 19(4):531-44 [DOI] 10.3233/XST-2011-0312. [PMID] 25214385.
2011
Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.
Arthritis research & therapy. 13(3) [DOI] 10.1186/ar3387. [PMID] 21708033.
2011
Distinctive Pattern of Myositis-Specific Autoantibody Production Between American Caucasian and Italian Patients With Polymyositis/Dermatomyositis
Arthritis and Rheumatism. 63
2011
First assessment of three-dimensional quantitative photoacoustic tomography for in vivo detection of osteoarthritis in the finger joints.
Medical physics. 38(7):4009-17 [PMID] 21858998.
2011
Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study.
Arthritis research & therapy. 13(3) [DOI] 10.1186/ar3334. [PMID] 21569292.
2011
Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies.
Clinical rheumatology. 30(10):1333-9 [DOI] 10.1007/s10067-011-1751-0. [PMID] 21523365.
2011
IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil.
Journal of immunology (Baltimore, Md. : 1950). 186(3):1747-54 [DOI] 10.4049/jimmunol.1001328. [PMID] 21191074.
2011
Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane.
Laboratory investigation; a journal of technical methods and pathology. 91(10):1540-50 [DOI] 10.1038/labinvest.2011.108. [PMID] 21808234.
2011
Transcription Intermediary Factor (Tif)-1 Beta Is a New Dermatomyositis Autoantigen
Arthritis and Rheumatism. 63
2011
Viral serpin therapeutics from concept to clinic.
Methods in enzymology. 499:301-29 [DOI] 10.1016/B978-0-12-386471-0.00015-8. [PMID] 21683260.
2010
Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.
Journal of neuroimmunology. 223(1-2):13-9 [DOI] 10.1016/j.jneuroim.2010.03.018. [PMID] 20416954.
2010
High-resolution x-ray guided three-dimensional diffuse optical tomography of joint tissues in hand osteoarthritis: morphological and functional assessments.
Medical physics. 37(8):4343-54 [PMID] 20879594.
2010
Image-guided optical spectroscopy in diagnosis of osteoarthritis: a clinical study.
Biomedical optics express. 1(1):74-86 [PMID] 21258447.
2010
Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus.
Arthritis research & therapy. 12(3) [DOI] 10.1186/ar3017. [PMID] 20478071.
2010
Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.
Genes and immunity. 11(7):542-53 [DOI] 10.1038/gene.2010.23. [PMID] 20445563.
2010
Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints.
Optics express. 18(14):14359-65 [DOI] 10.1364/OE.18.014359. [PMID] 20639920.
2009
Altered Homeostasis of Cd4+Memory T Cells in Peripheral Blood of Active Lupus Patients
Journal of Allergy and Clinical Immunology. 123(2):340-S91 [DOI] 10.1016/j.jaci.2008.12.324.
2009
Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis.
The Journal of rheumatology. 36(12):2682-90 [DOI] 10.3899/jrheum.090338. [PMID] 19884269.
2009
Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis.
Journal of biomedical optics. 14(5) [DOI] 10.1117/1.3233655. [PMID] 19895115.
2009
Defective Retinoic Acid Expansion of Foxp3+Regulatory T Cells in Lupus
Clinical Immunology. 131 [DOI] 10.1016/j.clim.2009.03.449.
2009
Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.
Arthritis research & therapy. 11(1) [DOI] 10.1186/ar2590. [PMID] 19144150.
2009
Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study.
Journal of biomedical optics. 14(6) [DOI] 10.1117/1.3257246. [PMID] 20059240.
2009
Type I interferon modulates monocyte recruitment and maturation in chronic inflammation.
The American journal of pathology. 175(5):2023-33 [DOI] 10.2353/ajpath.2009.090328. [PMID] 19808647.
2008
Clinical Significance of Autoantibodies To Topoisomerase I and Rna Polymerase Iii in An Unselected Rheumatic Disease Population
Arthritis and Rheumatism. 58:S372-S373
2008
Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen.
Journal of immunology (Baltimore, Md. : 1950). 181(5):3259-67 [PMID] 18713997.
2008
Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW)F(1) mice.
Toxicology letters. 183(1-3):1-9 [DOI] 10.1016/j.toxlet.2008.08.020. [PMID] 18951962.
2008
Defective B-cell response to T-dependent immunization in lupus-prone mice.
European journal of immunology. 38(11):3028-40 [DOI] 10.1002/eji.200838417. [PMID] 18924209.
2008
High Affinity Fc Gamma Receptor Ri (Cd64), a Potential Biomarker To Monitor Type-I-Ifn Levels and Disease Activity in Sle
Arthritis and Rheumatism. 58
2008
Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus.
Laboratory investigation; a journal of technical methods and pathology. 88(9):1008-20 [DOI] 10.1038/labinvest.2008.62. [PMID] 18607347.
2008
Patients with pulmonary tuberculosis are frequently positive for anti-cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptide.
Arthritis and rheumatism. 58(6):1576-81 [DOI] 10.1002/art.23514. [PMID] 18512773.
2008
Significant Racial and Gender Differences in Specificity of Scleroderma-Related Autoantibodies
Arthritis and Rheumatism. 58
2008
Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints.
Journal of biomedical optics. 13(4) [DOI] 10.1117/1.2965547. [PMID] 19021334.
2007
Acceleration of autoimmunity by organochlorine pesticides: a comparison of splenic B-cell effects of chlordecone and estradiol in (NZBxNZW)F1 mice.
Toxicological sciences : an official journal of the Society of Toxicology. 99(1):141-52 [PMID] 17578864.
2007
Autoantibodies to RNA helicase A: a new serologic marker of early lupus.
Arthritis and rheumatism. 56(2):596-604 [PMID] 17265494.
2007
Clinical implication of autoantibodies in patients with systemic rheumatic diseases.
Expert review of clinical immunology. 3(5):721-38 [DOI] 10.1586/1744666X.3.5.721. [PMID] 20477023.
2007
Deficiency of the type I interferon receptor protects mice from experimental lupus.
Arthritis and rheumatism. 56(11):3770-83 [PMID] 17968932.
2007
Diminished prolactin from chlordecone treatment in ovariectomized (NZBxNZW)F(1) mice.
International immunopharmacology. 7(13):1808-12 [PMID] 17996692.
2007
Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms.
Journal of immunology (Baltimore, Md. : 1950). 179(11):7439-47 [PMID] 18025188.
2007
Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints.
Journal of biomedical optics. 12(3) [PMID] 17614709.
2007
Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Arthritis and rheumatism. 56(11):3759-69 [PMID] 17968925.
2006
Comparison of chlordecone effects on autoimmunity in (NZBxNZW) F(1) and BALB/c mice.
Toxicology. 218(2-3):81-9 [PMID] 16309813.
2006
Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p.
Arthritis and rheumatism. 54(5):1573-9 [PMID] 16645992.
2006
Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane).
The American journal of pathology. 168(4):1227-40 [PMID] 16565497.
2006
Urinary biomarkers in lupus nephritis.
Autoimmunity reviews. 5(6):383-8 [PMID] 16890891.
2005
Acceleration of autoimmunity by organochlorine pesticides in (NZB x NZW)F1 mice.
Environmental health perspectives. 113(3):323-8 [PMID] 15743722.
2005
Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.). 117(3):238-50 [PMID] 16126005.
2005
Genetic dissection of systemic lupus erythematosus pathogenesis: partial functional complementation between Sle1 and Sle3/5 demonstrates requirement for intracellular coexpression for full phenotypic expression of lupus.
Journal of immunology (Baltimore, Md. : 1950). 175(2):1337-45 [PMID] 16002739.
2005
High sensitivity C-reactive protein in systemic lupus erythematosus: relation to disease activity, clinical presentation and implications for cardiovascular risk.
Lupus. 14(8):576-82 [PMID] 16175928.
2005
Induction of apoptosis by the hydrocarbon oil pristane: implications for pristane-induced lupus.
Journal of immunology (Baltimore, Md. : 1950). 175(7):4777-82 [PMID] 16177126.
2005
Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.
Journal of immunology (Baltimore, Md. : 1950). 175(2):1080-9 [PMID] 16002709.
2005
T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells.
The Journal of clinical investigation. 115(7):1869-78 [PMID] 15951839.
2004
Diagnostic accuracy for lupus and other systemic autoimmune diseases in the community setting.
Archives of internal medicine. 164(22):2435-41 [PMID] 15596633.
2004
Genetic dissection of lupus pathogenesis: Sle3/5 impacts IgH CDR3 sequences, somatic mutations, and receptor editing.
Journal of immunology (Baltimore, Md. : 1950). 173(12):7368-76 [PMID] 15585861.
2004
Mechanisms of peritoneal B-1a cells accumulation induced by murine lupus susceptibility locus Sle2.
Journal of immunology (Baltimore, Md. : 1950). 173(10):6050-8 [PMID] 15528340.
2004
Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis.
Arthritis and rheumatism. 50(6):1842-9 [PMID] 15188361.
2003
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950). 171(5):2270-8 [PMID] 12928371.
2002
Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cells.
Journal of immunology (Baltimore, Md. : 1950). 169(7):4025-32 [PMID] 12244205.
2002
The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells.
Journal of immunology (Baltimore, Md. : 1950). 169(5):2694-700 [PMID] 12193743.
1999
Aberrant expression of the NF-kappaB and IkappaB proteins in B cells from viable motheaten mice.
Autoimmunity. 30(2):115-28 [PMID] 10435725.
1999
Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow-derived B cells.
Journal of immunology (Baltimore, Md. : 1950). 162(4):2415-21 [PMID] 9973523.
1998
Functional consequences of the SHP-1 defect in motheaten viable mice: role of NF-kappa B.
Cellular immunology. 185(1):49-58 [PMID] 9636682.
1998
Novel immunoregulatory B cell pathways revealed by lpr-+ mixed chimeras.
Journal of immunology (Baltimore, Md. : 1950). 160(3):1497-503 [PMID] 9570572.
1998
Prevention of experimental allergic encephalomyelitis by an antibody to CD45RB.
Cellular immunology. 190(2):173-82 [PMID] 9878118.
1998
Resistance to HgCl2-induced autoimmunity in haplotype-heterozygous mice is an intrinsic property of B cells.
Journal of immunology (Baltimore, Md. : 1950). 161(4):1778-85 [PMID] 9712044.
1998
Use of phosphorothioate-modified oligodeoxynucleotides to inhibit NF-kappaB expression and lymphocyte function.
Clinical immunology and immunopathology. 86(2):170-9 [PMID] 9473379.
1997
B cell genotype determines the fine specificity of autoantibody in lpr mice.
Journal of immunology (Baltimore, Md. : 1950). 159(2):1027-35 [PMID] 9218626.
1997
Class II haplotype differentially regulates immune response in HgCl2-treated mice.
Clinical immunology and immunopathology. 84(3):328-37 [PMID] 9281392.
1997
Inhibition of the p50 (NKkappaB1) subunit of NF-kappaB by phosphorothioate-modified antisense oligodeoxynucleotides reduces NF-kappaB expression and immunoglobulin synthesis in murine B cells.
Clinical immunology and immunopathology. 83(3):254-63 [PMID] 9175914.
1996
Cellular interactions in the lpr and gld models of systemic autoimmunity.
Advances in dental research. 10(1):76-80 [PMID] 8934931.
1996
Hyperproliferation of BXSB B cells is linked to the Yaa allele.
Clinical immunology and immunopathology. 81(2):145-52 [PMID] 8906745.
1996
Phenotypic abnormalities of splenic and bone marrow B cells in lpr and gld mice.
Clinical immunology and immunopathology. 78(1):21-9 [PMID] 8599880.
1995
Co-infusion of normal bone marrow partially corrects the gld T-cell defect. Evidence for an intrinsic and extrinsic role for Fas ligand.
Journal of immunology (Baltimore, Md. : 1950). 154(1):459-64 [PMID] 7527822.
1995
In vivo depletion of Thy-1-positive cells originating from normal bone marrow abrogates the suppression of gld disease in normal-gld mixed bone marrow chimeras.
Journal of immunology (Baltimore, Md. : 1950). 154(1):444-9 [PMID] 7527820.
1995
The abnormal lpr double-negative T cell fails to proliferate in vivo.
Clinical immunology and immunopathology. 74(2):177-84 [PMID] 7828372.
1995
The Yaa gene-mediated acceleration of murine lupus: Yaa- T cells from non-autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo.
European journal of immunology. 25(12):3412-7 [PMID] 8566031.
1994
T-B collaboration for autoantibody production in lpr mice is cognate and MHC-restricted.
Journal of immunology (Baltimore, Md. : 1950). 152(12):6011-6 [PMID] 8207226.
1994
The role of B cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice.
Seminars in immunology. 6(1):49-54 [PMID] 8167307.
1993
Aberrant expression of the very early activation antigen on MRL/Mp-lpr/lpr lymphocytes.
Journal of immunology (Baltimore, Md. : 1950). 150(2):673-82 [PMID] 8380429.
1993
Antigen nonspecific effect of major histocompatibility complex haplotype on autoantibody levels in systemic lupus erythematosus-prone lpr mice.
The Journal of clinical investigation. 91(6):2761-8 [PMID] 7685774.
1993
Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice.
The Journal of experimental medicine. 177(1):69-78 [PMID] 8418209.
1993
Conventional B cells, not B1 cells, are the source of autoantibodies in chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950). 151(12):7316-23 [PMID] 7505027.
1993
Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.
International immunology. 5(10):1275-8 [PMID] 7505611.
1993
lpr T cells are necessary for autoantibody production in lpr mice.
Journal of immunology (Baltimore, Md. : 1950). 150(9):4160-7 [PMID] 8473754.
1992
The role of CD5+ B cells in the production of autoantibodies in murine systemic lupus erythematosus.
Annals of the New York Academy of Sciences. 651:588-90 [PMID] 1376085.
1991
An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.
The Journal of experimental medicine. 173(6):1441-9 [PMID] 2033370.

Grants

Jul 2020 – Jun 2022
Determinants of follicular helper T cell expansion in lupus
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2018 – May 2022
Characterization of SLE-susceptibility loci on mouse chromosome 1
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Dec 2016 – Jul 2022
Targeting follicular helper CD4 T cells in SLE
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2016 – Feb 2020
Targeting follicular helper CD4 T cells in SLE
Role: Co-Investigator
Funding: LUPUS RESEARCH ALLIANCE
May 2013 – Jun 2018
Characterization of SLE-susceptibility loci on mouse chromosome 1
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Feb 2013 – Jan 2016
CD4 T Cell Metabolism in SLE: Characterization and Target Identification
Role: Project Manager
Funding: LUPUS RESEARCH ALLIANCE

Education

Other Program – Rheumatology
1990 · University of North Carolina
Residency – Internal Medicine
1987 · University of North Carolina
Internship – Internal Medicine
1985 · University of North Carolina
Medical Degree
1984 · Case Western Reserve University
PhD
1983 · Case Western Reserve University

Contact Details

Phones:
Business:
(352) 265-4846
Emails:
Addresses:
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PO Box 100221
GAINESVILLE FL 32610
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ARB R2 114 JHMHC
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