Haoyang Zhuang

Haoyang Zhuang,

RES AST PROF

Department: MD-RHEUMATOLOGY
Business Phone: (352) 294-8218
Business Email: haoyang@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-1203-1993

Publications

2024
PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy
Journal of Experimental Medicine. 221(3) [DOI] 10.1084/jem.20231519. [PMID] 38334978.
2022
A novel monocyte differentiation pattern in pristane-induced lupus with diffuse alveolar hemorrhage.
eLife. 11 [DOI] 10.7554/eLife.76205. [PMID] 36264674.
2022
Microvascular lung injury and endoplasmic reticulum stress in systemic lupus erythematosus-associated alveolar hemorrhage and pulmonary vasculitis
American Journal of Physiology-Lung Cellular and Molecular Physiology. 323(6):L715-L729 [DOI] 10.1152/ajplung.00051.2022. [PMID] 36255715.
2021
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Nature communications. 12(1) [DOI] 10.1038/s41467-021-26091-4. [PMID] 34599187.
2021
Microscopic Polyangiitis With Diffuse Alveolar Hemorrhage and Glomerulonephritis Complicating Acute Influenza Infection.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 27(8S):S618-S619 [DOI] 10.1097/RHU.0000000000001730. [PMID] 33843777.
2021
Myxomavirus serpin alters macrophage function and prevents diffuse alveolar hemorrhage in pristane-induced lupus.
Clinical immunology (Orlando, Fla.). 229 [DOI] 10.1016/j.clim.2021.108764. [PMID] 34089860.
2021
Reply.
Arthritis & rheumatology (Hoboken, N.J.). 73(1):176-178 [DOI] 10.1002/art.41478. [PMID] 32776428.
2020
Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon.
Arthritis & rheumatology (Hoboken, N.J.). 72(1):100-113 [DOI] 10.1002/art.41072. [PMID] 31390156.
2020
NF-E2-Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus.
Arthritis & rheumatology (Hoboken, N.J.). 72(10):1707-1720 [DOI] 10.1002/art.41383. [PMID] 32500632.
2019
High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage.
JCI insight. 4(15) [DOI] 10.1172/jci.insight.129703. [PMID] 31391335.
2018
Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.00135. [PMID] 29456535.
2017
A Novel Subset of Anti-Inflammatory CD138+ Macrophages Is Deficient in Mice with Experimental Lupus.
Journal of immunology (Baltimore, Md. : 1950). 199(4):1261-1274 [DOI] 10.4049/jimmunol.1700099. [PMID] 28696256.
2017
Computational methods for 2D materials: discovery, property characterization, and application design.
Journal of physics. Condensed matter : an Institute of Physics journal. 29(47) [DOI] 10.1088/1361-648X/aa9305. [PMID] 29022886.
2017
Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus.
Arthritis & rheumatology (Hoboken, N.J.). 69(6):1280-1293 [DOI] 10.1002/art.40077. [PMID] 28217966.
2016
“Lupoid hepatitis” in SLE patients and mice with experimental lupus.
Clinical immunology (Orlando, Fla.). 172:65-71 [DOI] 10.1016/j.clim.2016.07.007. [PMID] 27430519.
2016
A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM.
Arthritis & rheumatology (Hoboken, N.J.). 68(12):2917-2928 [DOI] 10.1002/art.39781. [PMID] 27274010.
2015
Animal Models of Interferon Signature Positive Lupus.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00291. [PMID] 26097482.
2015
Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts.
PloS one. 10(8) [DOI] 10.1371/journal.pone.0136816. [PMID] 26305684.
2015
Maintenance of autoantibody production in pristane-induced murine lupus.
Arthritis research & therapy. 17 [DOI] 10.1186/s13075-015-0886-9. [PMID] 26717913.
2015
Mechanisms of autoantibody production in systemic lupus erythematosus.
Frontiers in immunology. 6 [DOI] 10.3389/fimmu.2015.00228. [PMID] 26029213.
2015
Mechanisms of tumor necrosis factor α antagonist-induced lupus in a murine model.
Arthritis & rheumatology (Hoboken, N.J.). 67(1):225-37 [DOI] 10.1002/art.38882. [PMID] 25252121.
2014
Phenotypic Consequences of Tlr7-Driven Interferon and Proinflammatory Cytokine Production in Lupus
Arthritis Research & Therapy. 16(1)
2014
Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin.
Clinical immunology (Orlando, Fla.). 154(1):49-65 [DOI] 10.1016/j.clim.2014.06.007. [PMID] 24971701.
2014
Toll-like receptor 7-stimulated tumor necrosis factor α causes bone marrow damage in systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.). 66(1):140-51 [DOI] 10.1002/art.38189. [PMID] 24449581.
2013
Cd40 Exon 8 Deficiency Causes a Novel Form of Immunodeficiency With Hyper-Igm
Journal of Immunology. 190
2013
Vorinostat, a histone deacetylase inhibitor, suppresses dendritic cell function and ameliorates experimental autoimmune encephalomyelitis.
Experimental neurology. 241:56-66 [DOI] 10.1016/j.expneurol.2012.12.006. [PMID] 23261766.
2012
Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.
Journal of immunology (Baltimore, Md. : 1950). 188(8):4113-21 [DOI] 10.4049/jimmunol.1103113. [PMID] 22422888.
2011
Design, synthesis and antimicrobial activity of chiral 2-(substituted-hydroxyl)-3-(benzo[d]oxazol-5-yl)propanoic acid derivatives.
European journal of medicinal chemistry. 46(9):3639-50 [DOI] 10.1016/j.ejmech.2011.05.028. [PMID] 21641699.
2011
Synthesis and antimicrobial evaluation of new benzofuran derivatives.
European journal of medicinal chemistry. 46(8):3526-30 [DOI] 10.1016/j.ejmech.2011.04.053. [PMID] 21570749.
2010
Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.
Journal of neuroimmunology. 223(1-2):13-9 [DOI] 10.1016/j.jneuroim.2010.03.018. [PMID] 20416954.
2010
Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus.
Arthritis research & therapy. 12(3) [DOI] 10.1186/ar3017. [PMID] 20478071.
2008
High Affinity Fc Gamma Receptor Ri (Cd64), a Potential Biomarker To Monitor Type-I-Ifn Levels and Disease Activity in Sle
Arthritis and Rheumatism. 58
2007
Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Arthritis and rheumatism. 56(11):3759-69 [PMID] 17968925.
2006
“Endogenous adjuvant” activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.
Arthritis and rheumatism. 54(5):1557-67 [PMID] 16645989.
2006
Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p.
Arthritis and rheumatism. 54(5):1573-9 [PMID] 16645992.
2006
Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers.
Vaccine. 24(19):4035-40 [PMID] 16464519.
2006
Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane).
The American journal of pathology. 168(4):1227-40 [PMID] 16565497.
2005
Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.). 117(3):238-50 [PMID] 16126005.

Grants

Sep 2017 – Aug 2023
PATHOGENESIS OF PRISTANE-INDUCED LUPUS
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS

Education

Ph.D.
2008 · University of Florida
B.S.
1998 · Nankai University

Contact Details

Phones:
Business:
(352) 294-8218
Emails:
Business:
haoyang@ufl.edu
Addresses:
Business Mailing:
PO Box 100221
GAINESVILLE FL 32610
Business Street:
1600 SW ARCHER RD ARB R2-156
GAINESVILLE FL 32603